Name: JOÃO VICTOR DA SILVA COUTINHO
Publication date: 13/05/2016
Advisor:
Name |
Role |
|---|---|
| JONES BERNARDES GRACELI | Advisor * |
Examining board:
| Name |
Role |
|---|---|
| JONES BERNARDES GRACELI | Advisor * |
| ROGER LYRIO DOS SANTOS | Internal Examiner * |
Summary: Tributyltin chloride (TBT) is an organometallic pollutant that is used as a biocide in antifouling paints. TBT induces several toxic and endocrine-disrupting effects. However, studies evaluating the effects of TBT on renal function are rare. This study demonstrates that TBT exposure is responsible for improper renal function as well as the development of abnormal morphophysiology in mammalian kidneys. Female rats were treated with TBT, and their renal morphophysiology was assessed. Morphophysiological abnormalities such as decreased glomerular filtration rates and increased proteinuria levels were observed in TBT rats. In addition, increases in inflammation, collagen deposition and α-smooth muscle action (α-SMA) protein expression were observed in TBT rat kidneys. A disrupted cellular redox balance and apoptosis in kidney tissue were also observed in TBT rats. TBT rats demonstrated reduced serum estrogen levels and kidney estrogen receptor-α (ERα) protein expression. Together, these data provide in vivo evidence that TBT is toxic to normal renal function and that these effects may be associated with renal histopathology complications.
Keywords: Tributyltin chloride, renal function, inflammation, estrogen, oxidative stress
